This book collects papers accepted by CENet2025 - the 15th International Conference on Computer Engineering and Networks, held in Hefei, China, 17-19 October 2025. The topics covered include Internet of Things and Smart Systems, Artificial Intelligence and Applications, Detection, Analysis and Application of Communication Systems, Cloud Computing and Security, and Medical Engineering and Information Systems. Each section of this book can serve as an excellent reference for industry practitioners, university faculty, research fellows, undergraduate and graduate students who wish to build a knowledge base of the latest advances and state-of-the-art practices in the topics covered. Using this knowledge, they will be able to design, implement and manage systems that are both complex and trustworthy. We would like to thank the authors for their hard work and dedication, and the reviewers for their efforts in ensuring that only the highest quality papers were selected. Without their contributions, the proceedings would not have been possible.