This volume is focused on the emerging concept of Collaborative Innovation Networks (COINs). COINs are at the core of collaborative knowledge networks, distributed communities taking advantage of the wide connectivity and the support of communication technologies, spanning beyond the organizational perimeter of companies on a global scale. It includes the refereed conference papers from the 6th International Conference on COINs, June 8-11, 2016, in Rome, Italy. It includes papers for both application areas of COINs, (1) optimizing organizational creativity and performance, and (2) discovering and predicting new trends by identifying COINs on the Web through online social media analysis. Papers at COINs16 combine a wide range of interdisciplinary fields such as social network analysis, group dynamics, design and visualization, information systems and the psychology and sociality of collaboration, and intercultural analysis through the lens of online social media. They will cover most recent advances in areas from leadership and collaboration, trend prediction and data mining, to social competence and Internet communication.