Nucleotides and Regulation of Bone Cell FunctionAuthor(s): Geoffrey Burnstock, Timothy R. Arnett\nFormat: Hardback\nPublisher: Taylor & Francis Inc, United States\nImprint: CRC Press Inc\nISBN-13: 9780849333682, 978-0849333682\nSynopsis\nATP's powerful impact on the heart and blood vessels was first described in 1929, but it was not until the 1970s that ATP was proposed as the 'purinergic' neurotransmitter in autonomic nerves. The door to this area of research was thrown open when receptors for ATP and its ectoenzymatic breakdown product adenosine were first cloned in the early 1990s. Now, rapidly accelerating research has taken scientists beyond the nervous system, to isolate receptors for purines and pyrimidines in many biological systems. Increasing evidence suggests that research into this area may lead to breakthrough applications in treating many of the most pressing health issues of today, including rheumatoid arthritis, osteoporosis, inflammation, and cancer.\n\nNucleotid.