Large Refill size. Eliminates unwanted mites from the very first spray Heavy infestation make take up to 24 hours This can help manage symptoms of Chronic Progressive Lymphedema (CPL). As Mites are the main cause of this ailment. With more severe cases clipping of the feathers is required to allow direct contact with the skin and remove more mites in the feathers East to use apply straight to the skin from the knee down no rinsing needed Continued use of this spray will unsure any new mites are dealt with on your horse. Added Eucalyptus oils No need to wash off